Axikin Pharmaceuticals
Axikin

Axikin is a biopharmaceutical company focused on the development of small molecule therapeutics for respiratory and inflammatory disorders.  One program centers around a highly-validated molecular entity on leukocytes that are the primary cell types activated in the allergic response — eosinophils, basophils, mast cells and lymphocytes of the T helper type 2 lineage. The target is a 7-transmembrane G-protein coupled receptor (GPCR) whose activation is linked to cell migration and activation.  Axikin scientists are now continuing to progress these lead candidates through pre-clinical IND-enabling studies.

Axikin also has two proprietary genomics targets in early discovery stages. One of these genes, a kinase, has been discovered following a microarray analysis of human lung tissue from patients with chronic obstructive lung disorder (COPD) and preliminary analyses have revealed a significant role for this gene in the production of highly relevant inflammatory mediators, and neutrophilic inflammation — a hallmark of the disease. This target will undergo further discovery analyses and testing to identify a small molecule therapeutic for COPD. Another proprietary target is a GPCR highly expressed in the lung and linked to pro-inflammatory activation and will continue to be developed with a goal of identifying small molecule antagonists for respiratory and inflammatory diseases.

 

Asthma
Asthma is a chronic inflammatory disorder of the airways in which patients may experience acute exacerbations.More

COPD
A group of diseases including emphysema and chronic bronchitis reflecting a progressive and irreversible loss of airway function. More

 

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